Bioinformatics scientist Interview Questions
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Bioinformatics Scientist interview questions shared by candidates
Can you manipulate bclfastq files?
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I described the pipeline I constructed.
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lots of script can do bclfastq, why ask this question?
Do you feel you would fit in a culture of rapid-change?
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Asking me about NGS experience, general and w/ PacBio.
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Described NGS functions in previous jobs.
Have you ever encountered batch effect or any technical effect. What was the impact on your data and how do you control for these unwanted variables.
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Use the ComBat function from the SVA Bioconductor package to combat batch effect
Some coding and statistics questions, some questions about NGS pipelines.
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Did you have to do a drug test?
NGS data analysis workflow/pipeline and tools
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The current "best" tools for differential expression analysis, e.g. DESeq2 and EdgeR, incorporate normalization factors accounting for library size and composition. Pointedly, these tools do not "just" normalize prior to analysis, they include the normalization factors as features within the model. If you are looking to utilize a neural network, hierarchical bayesian, or other type of machine learning approach to differential expression, determining the appropriate method of normalization will be a make or break point. Less
Why do you want to live in Iowa?
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Never been in a place with real seasons. I'm sure I'd get sick of winters, but I have a strong belief in experiencing as many different places as possible. I think JMI laboratories is doing good work in anti-bacterial research and I want to be a part of that, the location isn't as important. Less
In round 1 they get an overall picture of you and your future goals and give you some idea about their work. Second round they will ask questions about your research and especially try to evaluate how your research can help their tech.
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Just answer honestly with the pros and cons of your research and how it can be applied or not. Less