Worth it if your career path lies within representation
Pros
The connections, the gained experience, the HR department, and the prospects. Working here (as an assistant) is really only fruitful if your plan is to enter into the representation field as an end-goal. While it's certainly possible to use working here as a vehicle towards other ambitions (writing, production), the type of work required of you here is more geared toward training your cognitive ability in the business side of entertainment, and you'll hate it if your ultimate goals aren't related. If your goals *are* related to the business side, working here is probably the best medicine. It's hard work, and it requires thick skin in taking the occasional scolding (specifically depending on which manager you're covering), but if you can think quickly, your prospects here are very bright, and you're looking at a potential career that'll make you millions if you're good at what you do.
Cons
If you're looking to get into production, writing, acting, or anything related to the creative area of entertainment, this job will feel like hell, you'll be unsatisfied with your position most of the time, and it'll usually only serve getting you into another entry-level area of entertainment regarding the creative side. And that's only if you remain here as an assistant for at least one year. As stated above, this job only really is fully fruitful if your career goals are in entertainment business or repping clients. And if it is, prepare for a life-consuming career. This path is for those who actually like to work 60-70+ hours a week, and you won't yield well if you don't, unless you're established and have clients like De Niro. Though it'll take at least a decade to secure clients of that caliber, and again: that's only if you're good at what you do.